Ingredient Monographs

The Science Behind Every Ingredient

Each component of the Calizor formula is selected for its evidence-based role in skin health, dosed at clinically meaningful levels.

Vitamin B3

(Nicotinamide)600 mg

Mechanism of Action

Vitamin B is essential for cellular energy production, skin health, and metabolic function. It improves skin elasticity, reduces fine lines, minimizes pores, regulates sebum production, and reduces hyperpigmentation. It is highly effective for acne and inflammation.

Clinical Basis

Vitamin B deficiency causes severe skin issues, typically appearing as a symmetric, dark, scaly, or thick rash on sun-exposed areas (hands, face, neck). Symptoms often arise in spring/summer, characterized by burning, redness, and photosensitivity. Severe deficiency leads to "3 Ds": dermatitis, diarrhea, and dementia.

Zinc

(Zinc Citrate, 31% Zn)10 mg

Mechanism of Action

Zinc citrate provides bioavailable zinc, which regulates immune function, reduces neutrophil chemotaxis, and inhibits pro-inflammatory cytokines such as IL-1 and TNF-α. It also suppresses Cutibacterium acnes growth and inhibits 5-α-reductase activity, reducing sebum production. Additionally, zinc supports wound healing and epithelial barrier repair through its role in DNA synthesis and cell proliferation.

Clinical Basis

Multiple meta-analyses confirm that zinc supplementation reduces inflammatory acne lesion counts. Patients with acne have been shown to have significantly lower serum zinc levels than matched healthy controls.

Vitamin B6

(as Pyridoxal 5-Phosphate)5 mg

Mechanism of Action

Pyridoxal 5-phosphate (P5P) is the active coenzyme form of vitamin B6, directly involved in amino acid metabolism and neurotransmitter synthesis. It modulates inflammatory pathways by influencing cytokine production and supports homocysteine metabolism, reducing oxidative stress. P5P may also impact hormonal balance, indirectly affecting sebum production.

Clinical Basis

Clinical research demonstrates that Vitamin B6 works best as an adjunct targeting inflammation and metabolic pathways and used as part of a broader vitamin regimen (including niacinamide).

Copper

(Copper Bisglycinate Chelate 10%)1.5 mg

Mechanism of Action

Copper bisglycinate is a chelated form of copper bound to glycine, improving absorption and bioavailability compared to inorganic salts. Once absorbed, copper serves as a cofactor for enzymes like lysyl oxidase (collagen cross-linking), cytochrome c oxidase (cellular energy), and superoxide dismutase (antioxidant defense). These functions support connective tissue integrity, reduce oxidative stress, and regulate inflammatory signaling in skin.

Clinical Basis

Dermatology reviews note that copper plays a key role in collagen synthesis, wound healing, and antioxidant defense (e.g., via copper-dependent enzymes like superoxide dismutase), mechanisms directly relevant to acne and rosacea pathophysiology involving oxidative stress and inflammation.

Folic Acid

(Vitamin B9)500 mcg

Mechanism of Action

Folic acid is converted in the body to tetrahydrofolate (THF), a coenzyme essential for one-carbon transfer reactions involved in DNA synthesis, repair, and methylation. It supports rapid cell turnover by enabling nucleotide production and regulates homocysteine metabolism, which is linked to oxidative stress and inflammation. Through these pathways, folate influences epidermal cell proliferation, immune function, and overall skin homeostasis.

Clinical Basis

Studies show that lower folate levels are associated with increased oxidative stress and inflammatory skin conditions, and supplementation (typically ~400–800 mcg/day) help normalize these pathways and support skin repair.

Quercetin

(Quercetin Dihydrate 95%)50 mg

Mechanism of Action

Quercetin is a flavonoid with potent antioxidant and anti-inflammatory properties, scavenging reactive oxygen species and inhibiting lipid peroxidation. It downregulates NF-κB signaling and reduces release of histamine and pro-inflammatory cytokines from mast cells. These actions stabilize immune responses and may reduce skin inflammation and vascular reactivity.

Clinical Basis

Emerging research supports quercetin’s role in reducing inflammation and oxidative stress, both central to acne and rosacea, with typical supplemental doses ranging from 500–1,000 mg/day. While direct clinical trials are limited, its mast cell–stabilizing effects make it particularly promising for rosacea-related flushing and sensitivity.

Turmeric Extract

(Curcumin 95%)50 mg

Mechanism of Action

Curcumin is a polyphenol that exerts strong anti-inflammatory effects by inhibiting NF-κB, COX-2, and pro-inflammatory cytokines such as TNF-α and IL-6. It also has antimicrobial activity and reduces oxidative stress by enhancing endogenous antioxidant enzymes. Additionally, curcumin can modulate sebum production and influence keratinocyte proliferation.

Clinical Basis

Clinical and preclinical studies show curcumin (typically 500–1,500 mg/day) can reduce inflammatory acne lesions and improve skin healing, particularly when formulated for enhanced bioavailability. Evidence in rosacea is less robust but supports a role in reducing inflammation and erythema, making it a strong adjunctive option.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.